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Scientist Off-Target Screening and Characterization*

immatics biotechnologies

immatics biotechnologies

Posted on Monday, October 16, 2023
We are currently seeking a Scientist Off-Target Screening and Characterization* to support our team in the research and development of innovative immunotherapeutic products. You will work in Tuebingen (Germany) in an interdisciplinary environment with colleagues from all research and preclinical/ clinical development departments. Your analytical reasoning and action-oriented style as well as your organization and communication skills will contribute to the team’s success.
Your mission
Your main responsibilities will include but are not limited to the following tasks:

  • Characterization and direct identification of the recognized peptide space of T cell receptors (TCRs) or monoclonal antibodies (mAbs) directed against peptide:MHC targets employing state of the art mass spectrometry techniques.
  • In silico analyses and risk assessment of off-target peptides utilizing Immatics’ unique XPRESIDENT® platform. Advancement of prediction tools by integration of data from different ‘-omics’ approaches (e.g., transcriptomics, proteomics, immunopeptidomics). 
  • Independent coordination of your work in close interaction with a team of scientific experts from various departments. This includes communication and presentation in internal meetings and towards external partners.
Your profile
You hold a PhD degree in life sciences or biotechnology and have a proven track record in protein biochemistry. Ideally you have gained insights into TCR characterization using mass spectrometry or 3D protein structure analysis. Preferably, you have previous experience in large-scale data analysis and have already worked with relational databases or programming tools. Knowledge in cancer biology and cancer immunotherapy is advantageous. You take careful processing and documentation of your results for granted. Your scientific excellence, extraordinary analytical competence and communication skills enable you to successfully contribute to projects as part of a team and to present your work internally or to external partners from the pharmaceutical and biotech industry.
We expect a high degree of independent working, analytical reasoning and excellent communication skills in English. You embrace rapidly changing requirements with an open mind and show a high degree of flexibility in an environment which is marked by a constant striving for excellence. Your motivation is driven by your passion for innovation and science. You approach tasks in a structured, reliable and foresighted manner, combined with an elevated level of individual responsibility, enthusiasm and strong social skills.
Why us?
We are a committed and inspired team and cherish the collegial, highly motivated, and family-friendly atmosphere within Immatics. Our culture allows for a high level of originality, independent thinking, and initiative. We believe in supporting our employees’ professional and social skills: We enable them to join conferences and trainings as well as to enjoy our Immatics benefits – e.g., job bike, job ticket, Health Programs, childcare benefits, relocation allowance, Company summer and winter events.
*We value diversity and inclusion. Immatics N.V. and all Immatics subsidiaries are equal opportunity employers that evaluate qualified applicants without regard to race, color, national origin, religion, sex, age, marital status, disability, veteran status, sexual orientation, gender identity, or other characteristics protected by law.
About Us
Immatics combines the discovery of true targets for cancer immunotherapies with the development of the right T cell receptors with the goal of enabling a robust and specific T cell response against these targets.

This deep know-how is the foundation for our pipeline of Adoptive Cell Therapies and TCR Bispecifics as well as our partnerships with global leaders in the pharmaceutical industry. We are committed to delivering the power of T cells and to unlocking new avenues for patients in their fight against cancer.